Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells
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چکیده
منابع مشابه
Channel gating forces govern accuracy of mechano-electrical transduction in hair cells.
Sensory hair cells are known for the exquisite displacement sensitivity with which they detect the sound-evoked vibrations in the inner ear. In this article, we determine a stochastically imposed fundamental lower bound on a hair cell's sensitivity to detect mechanically coded information arriving at its hair bundle. Based on measurements of transducer current and its noise in outer hair cells ...
متن کاملSensory Neuron Mechanotransduction, Mechanisms and Molecules Detecting Sound: Mechano-electrical Transduction in the Ear
Somatic sensation is overwhelmingly felt as the result of mechanical stimulation or movement of the body or its parts. Indeed almost all tissues of the body receive an innervation from the peripheral axons of mechanosensitive sensory neurons with their cell body in the dorsal root or trigeminal ganglia. Remarkably, the mechanisms and molecules used by sensory neurons to transform mechanical for...
متن کاملTransduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.
Tip links between adjacent stereocilia are believed to gate mechano-electrical transducer (MET) channels and mediate the electrical responses of sensory hair cells. We found that mouse auditory hair cells that lack tip links due to genetic mutations or exposure to the Ca(2+) chelator BAPTA can, however, still respond to mechanical stimuli. These MET currents have unusual properties and are pred...
متن کاملThe transduction channel filter in auditory hair cells.
In the first step in auditory transduction, sound-induced vibrations of the stereociliary bundles on the sensory hair cells are converted into electrical signals by opening of mechanotransducer channels. Faithful transduction and hence auditory performance will be limited by the kinetic properties of these channels. We have measured the time course of mechanotransducer currents in turtle and ra...
متن کاملThe acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI
KEY POINTS The transduction of sound into electrical signals occurs at the hair bundles atop sensory hair cells in the cochlea, by means of mechanosensitive ion channels, the mechano-electrical transducer (MET) channels. The MET currents decline during steady stimuli; this is termed adaptation and ensures they always work within the most sensitive part of their operating range, responding best ...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2019
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007635